Characterization and functional analysis of a novel C1q-domain-containing protein in Japanese flounder (Paralichthys olivaceus)

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• 作者：Lei Wang^a ; ^b ; ¹ ; Caixia Fan^a ; ^b ; ¹ ; Wenteng Xu^a ; ^b ; Yongzhen Zhang^a ; ^b ; Zhongdian Dong^a ; ^b ; Jinsong Xiang^a ; ^b ; Songlin Chen^a ; ^b ; ^{chensl@ysfri.ac.cn}
• 关键词：Japanese flounder ; PoC1ql3 ; Complement system ; Pathogen-recognition receptor ; Antibacterial function
• 刊名：Developmental & Comparative Immunology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：67
• 期：Complete
• 页码：322-332
• 全文大小：2876 K
• 卷排序：67

文摘

Characterization of a novel C1q-domain-containing protein of the Japanese flounder. PoC1ql3 was expressed not only in the brain, but also in many immune-related tissues. C1ql3-full and C1ql3-part protein exerted antimicrobial function against E. tarda in vitro. The C1ql3-part bound LPS and PGN as pattern-recognition receptor. The C1ql3-part inhibited the invasion of bacterium to fish kidney cells in vivo.