Isolation and characterization of a Far-Eastern strain of tick-borne encephalitis virus in China
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- 作者：Xiaowei Zhanga ; b ; Zhenhua Zhenga ; b ; Bo Shub ; Panyong Maoc ; Bingke Baic ; Qinxue Hub ; Zongqiang Cuib ; Hanzhong Wanga ; b ; wanghz@wh.iov.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tick-borne encephalitis virus ; China ; Human brain-derived cell lines ; Growth curve ; Encephalitis
- 刊名：Virus Research
- 出版年：2016
- 出版时间：2 February 2016
- 年：2016
- 卷：213
- 期：Complete
- 页码：6-10
- 全文大小：1379 K
文摘
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A novel TBEV strain (WH2012) was isolated from northern China and its full-length genome was sequenced.
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WH2012 was capable of inducing cytopathic effects in human brain-derived cell lines of three origins.
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WH2012 replicated most efficiently in human neuroblastoma cells SK-N-SH.
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Intracerebral inoculation of virus led to complete paralysis in the hindlimbs and 100% mortality in mice.