Assessment of sodium channel mutations in Makah tribal members of the U.S. Pacific Northwest as a potential mechanism of resistance to paralytic shellfish poisoning
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- 作者：Nicolaus G. Adamsa ; nicolaus.adams@noaa.gov" class="auth_mail" title="E-mail the corresponding author ; Alison Robertsonb ; c ; Lynn M. Grattand ; Steve Pendletone ; Sparkle Robertsd ; J. Kathleen Tracyd ; Vera L. Trainera
- 关键词：Voltage-gated Na+ channel ; Paralytic shellfish poisoning ; Saxitoxin ; Resistance ; Harmful algal blooms
- 刊名：Harmful Algae
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：57
- 期：part_PB
- 页码：26-34
- 全文大小：1292 K
文摘
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Skeletal muscle Na+ (Nav1.4) channels of Makah members were sequenced at 9 loci.
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Sequences were analyzed for variations potentially conferring saxitoxin resistance.
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No mutations at saxitoxin binding sites in sodium channel pore regions were observed.
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Nav1.4 channels likely do not confer saxitoxin resistance in Makah Tribe members.