Synthesis of tetra-substituted pyrroles, a potential phosphodiesterase 4B inhibitor, through nickel(II) chloride hexahydrate catalyzed one-pot four-component reaction
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- 作者：Abu T. Khan ; Mohan Lal ; Prasanta Ray Bagdi ; R. Sidick Basha ; Parameswaran Saravanan ; Sanjukta Patra
- 关键词：Multicomponent reactions ; ¦Â-Ketoesters ; Nickel(II) chloride hexahydrate ; Tetra-substituted pyrroles ; Docking studies ; Phosphodiesterase 4B inhibitor
- 刊名：Tetrahedron Letters
- 出版年：2012
- 出版时间：8 August, 2012
- 年：2012
- 卷：53
- 期：32
- 页码：4145-4150
- 全文大小：1136 K
文摘
A wide variety of tetra-substituted pyrrole derivatives were synthesized through one-pot four-component condensation reaction of aromatic aldehydes, benzylamines, ¦Â-ketoesters, and nitroalkanes in the presence of 10 mol % NiCl2¡¤6H2O in good yields. Some of them exhibit properties as potential inhibitors of phosphodiesterase 4B (PDE4B) through docking studies.