CHNQ, a novel 2-Chloro-1,4-naphthoquinone derivative of quercetin, induces oxidative stress and autophagy both in vitro and in vivo
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- 作者：Shabnam Enayata ; 1 ; M. Şeyma Ceyhana ; 1 ; Betü ; l Taşkoparana ; Milan Stefekb ; Sreeparna Banerjeea ; banerjee@metu.edu.tr" class="auth_mail" title="E-mail the corresponding author
- 关键词：CHNQ ; Quercetin ; Colon cancer ; Oxidative stress ; Autophagy
- 刊名：Archives of Biochemistry and Biophysics
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：596
- 期：Complete
- 页码：84-98
- 全文大小：3569 K
文摘
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CHNQ, a quercetin derivative, showed higher cytotoxicity in colon cancer cell lines.
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CHNQ reduced proliferation and induced apoptosis in colon cancer cells.
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CHNQ strongly induced the formation of reactive oxygen species and G2/M arrest.
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Robust ROS induced autophagy was seen in colon cancer cells treated with CHNQ.
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CHNQ treatment induced ROS and autophagy in