Paraoxonase and atherosclerosis-related cardiovascular diseases

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• 作者：Dimitry A. Chistiakov^a ; Alexandra A. Melnichenko^b ; ^c ; Alexander N. Orekhov^b ; ^c ; ^d ; ^e ; Yuri V. Bobryshev^b ; ^f ; ^g ; ^{y.bobryshev@unsw.edu.au}
• 关键词：Paraoxonase ; PON1 ; PON2 ; PON3 ; Atherosclerosis ; Atheroprotective properties
• 刊名：Biochimie
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：132
• 期：Complete
• 页码：19-27
• 全文大小：954 K
• 卷排序：132

文摘

Three human paraoxonase PON1, PON2, and PON3 genes are clustered on chromosome 7. PONs possess numerous atheroprotective properties. PON polymorphisms contribute to susceptibility/protection from atherosclerosis. PON properties make PON to be a promising target for therapeutic strategies.