Host cell remodelling in malaria parasites: a new pool of potential drug targets

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• 作者：Paul R. Gilson^a ; ^b ; ^{gilson@burnet.edu.au} ; Scott A. Chisholm^c ; Brendan S. Crabb^a ; ^b ; ^d ; Tania F. de Koning-Ward^c
• 关键词：Malaria ; Plasmodium falciparum ; Host cell modification ; Translocon ; Protein export ; Virulence
• 刊名：International Journal for Parasitology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：47
• 期：2-3
• 页码：119-127
• 全文大小：529 K
• 卷排序：47

文摘

Plasmodium parasites extensively modify their human host cells to survive. The parasites modify their host cells by exporting hundreds of effector proteins into them. Many exported proteins are essential for parasite survival and virulence. Blocking the parasite’s protein trafficking machinery with drug inhibitors arrests parasite growth. The protein trafficking machinery is a novel drug target.