PSA-NCAM in the posterodorsal medial amygdala is necessary for the pubertal emergence of attraction to female odors in male hamsters
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- 作者：Martin O. Job ; Bradley M. Cooke ; bcooke@gsu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：BNSTpm ; bed nucleus of the stria terminalis ; posteromedial division ; DG ; dentate gyrus ; LHb ; lateral habenula ; MHb ; medial habenula ; LGNvl ; lateral geniculate thalamic nucleus ; ventrolateral division ; LSvl ; ventrolateral septum ; st ; stria terminalis ; MeA ; medial amygdala ; MePD ; posterodorsal subdivision of the medial amygdala ; PSA-NCAM ; polysialylated neural cell adhesion molecule ; PSA ; polysialic acid ; PVP ; posterior paraventricular thalamic nucleus ; SON ; supraoptic nucleus
- 刊名：Hormones and Behavior
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：75
- 期：Complete
- 页码：91-99
- 全文大小：1245 K
文摘
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We found that attraction to female odors emerges at postnatal day 37 in male Syrian hamsters.
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We then measured the level of polysialylated neural cell adhesion molecule (PSA-NCAM) in numerous brain regions.
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PSA-NCAM was selectively elevated in the posterodorsal medial amygdala, just before the emergence of opposite sex attraction
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Serum T was unrelated to PSA-NCAM in the MePD, but was inversely related to it in the habenula and thalamus.
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Depletion of polysialic acids from posterodorsal medial amygdala blocked the emergence of attraction to female odors.