mRNA GPR162 changes are associated with decreased food intake in rat, and its human genetic variants with impairments in glucose homeostasis in two Swedish cohorts
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- 作者：Vanni Carusoa ; b ; 1 ; vanni.caruso@neuro.uu.se" class="auth_mail" title="E-mail the corresponding author ; Smitha Sreedharana ; 1 ; Valeria P. Carlinia ; c ; Josefin A. Jacobssona ; Tatjana Haitinaa ; Joanna Hammera ; Olga Stephanssona ; Filip Cronaa ; Wolfgang H. Sommerd ; Ulf Risé ; ruse ; Lars Lannfeltf ; Claude Marcusg ; Markus Heiligh ; Susana R. de Barioglioc ; Robert Fredrikssona ; Helgi B. Schiö ; tha
- 关键词：ZI ; Zona incerta ; STN ; Subthalamic nucleus ; PSth ; Parasubthalamic nucleus ; BLA ; Basolateral nucleus of the amygdala ; LaDL ; Lateral amygdaloid nucleus dorsolateral part ; Den ; Dorsal endopiriform claustrum ; ACo ; Anterior cortical amygdaloid area ; SO ; Supraoptic nucleus ; LD ; Laterodorsal thalamic nuclei ; LH ; Lateral hypothalamus ; MH ; Medial hebanula ; MD ; Mediodorsal thalamic nuclei ; PV ; Paraventricular thalamic nucleus ; CM ; Central medial thalamic nucleui ; PAG ; Periaqueductal gray ; VTA ; Ventral teg
- 刊名：Gene
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：581
- 期：2
- 页码：139-145
- 全文大小：1208 K
文摘
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We completed the anatomical characterization of GPR162 complementing a species-specific mapping of the gene in both mouse and rat.
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We reported a functional implication of GPR162 in food intake-related behavior via antisense knockdown studies.
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Variants of the GPR162 gene are associated with impairments in glucose homeostasis in two Swedish cohorts.