Depressed basal hypothalamic neuronal activity in type-1 diabetic mice is correlated with proinflammatory secretion of HMBG1
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- 作者：Jeffrey S. Thinschmidta ; Luis M. Colon-Perezb ; Marcelo Febob ; Sergio Caballeroa ; Michael A. Kinga ; Fletcher A. Whitec ; Maria B. Grantd ; mabgrant@iupui.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Akita ; HMBG1 ; MEMRI ; Diabetes ; Neuroinflammation
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：26 February 2016
- 年：2016
- 卷：615
- 期：Complete
- 页码：21-27
- 全文大小：1635 K
文摘
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Hypothalamic neuronal activity is reduced following 8 months of type-1 diabetes in mice.
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Basal neuronal activity is reduced in the paraventricular nucleus (PVN) following 8 months of type-1 diabetes in mice.
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Nuclear localization of HMBG1 is reduced in the paraventricular nucleus (PVN) of the hypothalamus following 8 months of type-1 diabetes in mice.
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Reduced nuclear localization of HMBG1 is correlated with a reduction in basal neuronal activity in the hypothalamus following 8 months of type-1 diabetes in mice.