Endocannabinoid 2-AG and intracellular cannabinoid receptors modulate a low-threshold calcium spike-induced slow depolarizing afterpotential in rat thalamic paraventricular nucleus neurons
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- 作者：L. Zhang&dagger ; ; M. Kolaj&dagger ; ; L.P. Renaud ; lprenaud@ohri.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACSF ; artificial cerebrospinal fluid ; CBR ; cannabinoid receptor ; DAG ; diacylglycerol ; DAGL ; DAG lipase ; FAAH ; fatty acid amide hydrolase ; LTS ; low-threshold spike ; MAGL ; monoacylglycerol lipase ; PAP ; phosphatic acid phosphohydrolase ; PA ; phosphatidic acid ; PC ; phosphatidylcholine ; PI ; phosphatidylinositol ; PLC ; phospholipase C ; PLD ; phospholipase D ; PVT ; paraventricular thalamic nucleus ; sADP ; slow afterdepolarization ; THL ; tetrahydrolipstatin ; TRPC ; transient receptor potential canonical ; TRH
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：13 May 2016
- 年：2016
- 卷：322
- 期：Complete
- 页码：308-319
- 全文大小：571 K
文摘
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LTS engages novel signaling pathways in PVT neurons.
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LTS-induced sADP is mediated via TRPC-like channels.
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sADP involves activation of phosphatidylcholine-specific PLD to generate DAG.
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DAGL activation leads to increase level of 2-AG during the LTS.
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LTS-induced sADP engages intracellular postsynaptic cannabinoid receptors.