Effects of histamine and cholinergic systems on memory retention of passive avoidance learning in rats

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• 作者：Eidi ; Maryam ; Zarrindast ; Mohammad-Reza ; Eidi ; Akram ; Oryan ; Shahrbanoo ; Parivar ; Kazem
• 关键词：Memory retention ; Passive avoidance ; Cholinoceptor drug ; Histaminergic agent ; (Rat)
• 刊名：European Journal of Pharmacology
• 出版年：2003
• 出版时间：March 28, 2003
• 年：2003
• 卷：465
• 期：1-2
• 页码：91-96
• 全文大小：168 K

文摘

In the present study, the effects of the histamine and cholinergic systems on memory retention in adult male rats were investigated. Post-training intracerebroventricular injections were carried out in all the experiments. Cholinoceptor agonist, acetylcholine (1–10 μg/rat) or nicotine (1–10 μg/rat), increased, while a cholinoceptor antagonist, scopolamine (5–20 μg/rat), decreased memory retention. The response to acetylcholine was attenuated by scopolamine. Administration of histamine (5–20 μg/rat) reduced, but the histamine H₁ receptor antagonist, pyrilamine (10–50 μg/rat), and the histamine H₂ receptor antagonist, cimetidine (1–50 μg/rat), increased memory retention in rats. The histamine receptor antagonists attenuated the response to histamine. Histamine reduced the acetylcholine- or nicotine-induced enhancement. The histamine receptor antagonists enhanced the nicotine- or acetylcholine-induced response. Histamine potentiated the inhibitory effect induced by scopolamine. It is concluded that histaminergic and cholinergic systems have opposing effects on memory retention. Also, the histaminergic system elicits an interaction with the cholinergic system in memory retention.