The Cohesive Metastasis Phenotype in Human Prostate Cancer

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• 作者：William L. Harryman^a ; James P. Hinton^b ; Cynthia P. Rubenstein^b ; Parminder Singh ; M.D.^a ; Raymond B. Nagle ; M.D. ; Ph.D.^a ; Sarah J. Parker ; Ph.D.^c ; Beatrice S. Knudsen ; M.D. ; Ph.D.^c ; Anne E. Cress ; Ph.D.^a ; ^{cress@email.arizona.edu}
• 关键词：ADT ; androgen-depletion therapy ; AR ; androgen receptor ; BPH ; benign prostatic hypertrophy ; CAM-DR ; cell adhesion-mediated drug resistance ; CAM-RR ; cell adhesion-mediated radiation resistance ; CD49f ; alpha-6 integrin sub-unit ; CK ; cytokeratin ; CTC ; circulating tumor cell ; DTC ; disseminated tumor cell ; ECM ; extracellular matrix ; EGF ; epidermal growth factor ; EGFR ; epidermal growth factor receptor ; EMT ; epithelial-to-mesenchymal transition ; EpCAM ; epithelial cell adhesion molecule ; ER ; estrogen rec
• 刊名：Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：1866
• 期：2
• 页码：221-231
• 全文大小：1301 K
• 卷排序：1866

文摘

The cohesive cluster phenotype is prominent in primary and metastatic human prostate cancer. The cancer cluster is in part dependent on adhesion molecules, a targetable phenotype independent of genomic heterogeneity of constituent cells. Targeting laminin-binding integrin cell-cell adhesion functions will disrupt cancer clusters. Disrupting the cancer cluster may prevent successful survival and colonization in metastasis. Disrupting the cancer cluster may overcome cell adhesion mediated drug and radiation resistance.