Cognitive screening in Parkinson's disease: Comparison of the Parkinson Neuropsychometric Dementia Assessment (PANDA) with 3 other short scales

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• 作者：A.-I. Gasser^a ; ^{anne-isabelle.gasser@h-fr.ch" class="auth_mail" title="E-mail the corresponding author} ; P. Calabrese^b ; E. Kalbe^c ; ^d ; J. Kessler^d ; P. Rossier^a
• 关键词：Parkinson's disease ; Dementia ; Cognitive impairment ; Screening test ; Neuropsychological assessment ; Cognition
• 刊名：Revue Neurologique
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：172
• 期：2
• 页码：138-145
• 全文大小：823 K

文摘

Cognitive screening is crucial in Parkinson's disease (PD). However, there is still a lack of short tools in French. In this study, we aimed to compare the Parkinson Neuropsychometric Dementia Assessment (PANDA) with the Mini Mental Parkinson (MMP), the Mini Mental State Examination (MMSE) and the Clock Test in French-speaking patients. We also aimed to propose cut-off scores for cognitive impairment and dementia for the French language version of the PANDA.

Method

Fifty-one patients with PD took the PANDA, the MMSE, the MMP, and the Clock Test. They also underwent extensive neuropsychological testing by a neuropsychologist who was blinded to the above-mentioned screening test results. Patients were classified as either having normal cognition (n = 15), mild cognitive impairment (n = 20) or dementia (n = 16).

Results

When compared with the three other screening tools, the PANDA exhibited the highest area under the curve (AUC) for both cognitive disorders and dementia. Using the cut-off scores proposed for the German version, the PANDA had 94% specificity and 100% sensitivity for dementia and 100% and 72%, respectively for cognitive disorders.

Conclusions

In our study, the PANDA exhibited a higher discriminative power than the three other tests in detecting cognitive disorders and dementia. In PD patients, the PANDA should thus be considered for the detection of cognitive impairment in routine clinical practice.