Xanthones as inhibitors of microsomal lipid peroxidation and TNF-α induced ICAM-1 expression on human umbilical vein endothelial cells (HUVECs)

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• 作者：Madan ; Babita ; Singh ; Ishwar ; Kumar ; Ajit ; Prasad ; Ashok K. ; Raj ; Hanumantharao G. ; Parmar ; Virinder S. ; et. al.
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2002
• 出版时间：November, 2002
• 年：2002
• 卷：10
• 期：11
• 页码：3431-3436
• 全文大小：154 K

文摘

Xanthones bearing different functionalities, namely 1-hydroxyxanthone (1), 3-hydroxyxanthone (2), 1,4-dihydroxyxanthone (3), 2,6-dihydroxyxanthone (4), 1,2-diacetoxyxanthone (5), 2,6-diacetoxyxanthone (6), 3-methoxyxanthone (7), 1,3,7-trimethoxyxanthone (8) and 1,5-dihydroxy-6-methoxyxanthone (9) were synthesised and examined for their effect on nicotinamide adenine dinucleotide phosphate (NADPH)-catalysed liver microsomal lipid peroxidation and on tumour necrosis factor-α (TNF-α) induced expression of intercellular adhesion moledule-1 (ICAM-1) on endothelial cells, with a view to establish structure–activity relationship. Hydroxy- and acetoxyxanthones showed potent inhibitory effects on NADPH-catalysed lipid peroxidation and TNF-α induced expression of ICAM-1 on endothelial cells.