文摘
Inhibition or depletion of PARP-1 promotes the adipogenic differentiation program PARP-1 PARylates C/EBPβ on three residues in a conserved regulatory domain PARylation of C/EBPβ inhibits DNA binding, transcriptional activity, and adipogenesis Mutation of the C/EBPβ PARylation sites produces a superactive transcription factor