The structure of porcine parvovirus: comparison with related viruses
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- 作者：Simpson ; Alan A. ; Hé ; bert ; Benoî ; t ; Sullivan ; Gail M. ; Parrish ; Colin R. ; Zá ; dori ; Zoltá ; n ; et. al.
- 关键词：porcine parvovirus ; X-ray crystallography ; structure ; host range ; tissue tropism ; PPV ; porcine parvovirus ; CPV ; canine parvovirus ; MVM ; minute virus of mice ; FPV ; feline panleukopenia virus ; VP ; viral protein ; AAV ; adeno-associated virus ; ss ; single-stran
- 刊名：Journal of Molecular Biology
- 出版年：2002
- 出版时间：February 1, 2002
- 年：2002
- 卷：315
- 期：5
- 页码：1189-1198
- 全文大小：866 K
文摘
The structure of baculovirus-expressed porcine parvovirus (PPV) capsids was solved using X-ray crystallography and was found to be similar to the related canine parvovirus (CPV) and minute virus of mice (MVM). The PPV capsid protein has 57 % and 49 % amino acid sequence identity with CPV and MVM, respectively, but the degree of conservation of surface-exposed residues is lower than average. Consequently, most of the structural differences are on the surface and are the probable cause of the known variability in antigenicity and host range.