Design, synthesis and biological evaluation of potent NAD⁺-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-Amino-pyrido[2,3-d]pyrimidin-5(8H)-ones

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• 作者：Tiansheng Wang ; ^{tiansheng_wang@vrtx.com} ; Leonard Duncan ; Wenxin Gu ; Hardwin O&rsquo ; Dowd ; Yunyi Wei ; Emanuele Perola ; Jonathan Parsons ; Christian H. Gross ; Cameron Stuver Moody ; S.J. Ryan Arends ; Paul S. Charifson
• 关键词：Antibiotics ; NAD ; DNA ligase ; Pyridopyrimidinone ; Inhibitor
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2012
• 出版时间：1 June, 2012
• 年：2012
• 卷：22
• 期：11
• 页码：3699-3703
• 全文大小：990 K

文摘

A series of 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones were designed and synthesized as a novel class of inhibitors of NAD⁺-dependent DNA ligase that possess potency against Gram-positive bacteria.