Peripheral nerve injury induces aquaporin-4 expression and astrocytic enlargement in spinal cord
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- 作者：M.K. Oklinski ; H.-J. Choi ; T.-H. Kwon ; thkwon@knu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：3D ; three-dimension ; ACSF ; artificial cerebrospinal fluid ; AQP4 ; aquaporin-4 ; BSCB ; blood&ndash ; spinal cord barrier ; CCI ; chronic constriction injury ; CNS ; central nervous system ; EAAT2 ; excitatory amino acid transporter 2 ; EB ; Evans Blue ; GFAP ; glial fibrillary acidic protein ; GS ; glutamine synthetase ; Na-Flu ; sodium fluorescein ; NF 200 ; Neurofilament 200 ; PBS ; phosphate-buffered saline ; PNI ; peripheral nerve injury ; PST ; partial sciatic nerve transection
- 刊名：Neuroscience
- 出版年：2015
- 出版时间：17 December 2015
- 年：2015
- 卷：311
- 期：Complete
- 页码：138-152
- 全文大小：3828 K
文摘
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Peripheral nerve injury per se was associated with long-lasting AQP4 up-regulation in the lumbar region of the spinal cord.
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Up-regulation of AQP4 was accompanied by a significant increase in the length and volume of astrocytic processes.
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The most prominent morphometric changes were present in the distal processes of the astrocytes.
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Extravasation of systemically administered tracers was not seen in the spinal cords after peripheral nerve injury.