Downregulation of the spinal dorsal horn clock gene Per1 expression leads to mechanical hypersensitivity via c-jun N-terminal kinase and CCL2 production in mice
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- 作者：Norimitsu Morioka ; mnori@hiroshima-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Munenori Saeki ; Tatsuhiko Sugimoto ; Takuya Higuchi ; Fang Fang Zhang ; Yoki Nakamura ; Kazue Hisaoka-Nakashima ; Yoshihiro Nakata
- 关键词：CCL2 ; chemokine (C-C motif) ligand 2 ; CCR2 ; CCL2 receptor ; Cry ; cryptochrome ; ERK ; extracellular signal-regulated kinase ; GAPDH ; glyceraldehydes-3-phosphate dehydrogenase ; GFAP ; glial fibrillary acidic protein ; HVJ ; hemagglutinating virus of Japan ; 5-HT ; 5-hydroxytriptamine ; JNK ; c-jun N-terminal kinase ; MAP ; mitogen-activated protein ; MCP-3 ; monocyte chemotactic protein ; NA ; noradrenaline ; PMSF ; phenylmethylsulfonyl fluoride ; PSNL ; partial sciatic nerve ligation ; Per ; period ; SCN ; suprachiasmat
- 刊名：Molecular and Cellular Neuroscience
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：72
- 期：Complete
- 页码：72-83
- 全文大小：3630 K
文摘
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The spinal dorsal horn Per1 decreases following a peripheral nerve injury.
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PER1 expression is decreased in the spinal dorsal horn neurons and astrocytes.
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Reduction of Per1 expression increases JNK phosphorylation in the spinal dorsal horn.
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Reduction of Per1 expression increases CCL2 production in the spinal dorsal horn.
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Per1 knockdown leads to JNK phosphorylation, CCL2 production and allodynia.