Precise spatial control of cavitation erosion in a vessel phantom by using an ultrasonic standing wave

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• 作者：Aiwei Shi ; Peixuan Huang ; Shifang Guo ; Lu Zhao ; Yingjie Jia ; Yujin Zong ; ^{yjzong@mail.xjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Mingxi Wan ; ^{mxwan@mail.xjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Cavitation ; Erosion ; Ultrasonic standing wave ; Vessel ; SonoVue ; Phase-change nanoemulsion
• 刊名：Ultrasonics Sonochemistry
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：31
• 期：Complete
• 页码：163-172
• 全文大小：1838 K

文摘

In atherosclerotic inducement in animal models, the conventionally used balloon injury is invasive, produces excessive vessel injuries at unpredictable locations and is inconvenient in arterioles. Fortunately, cavitation erosion, which plays an important role in therapeutic ultrasound in blood vessels, has the potential to induce atherosclerosis noninvasively at predictable sites. In this study, precise spatial control of cavitation erosion for superficial lesions in a vessel phantom was realised by using an ultrasonic standing wave (USW) with the participation of cavitation nuclei and medium-intensity ultrasound pulses. The superficial vessel erosions were restricted between adjacent pressure nodes, which were 0.87 mm apart in the USW field of 1 MHz. The erosion positions could be shifted along the vessel by nodal modulation under a submillimetre-scale accuracy without moving the ultrasound transducers. Moreover, the cavitation erosion of the proximal or distal wall could be determined by the types of cavitation nuclei and their corresponding cavitation pulses, i.e., phase-change microbubbles with cavitation pulses of 5 MHz and SonoVue microbubbles with cavitation pulses of 1 MHz. Effects of acoustic parameters of the cavitation pulses on the cavitation erosions were investigated. The flow conditions in the experiments were considered and discussed. Compared to only using travelling waves, the proposed method in this paper improves the controllability of the cavitation erosion and reduces the erosion depth, providing a more suitable approach for vessel endothelial injury while avoiding haemorrhage.