Encapsulation of perfluorocarbon gases into lipid-based carrier by PGSS

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• 作者：S. Rodr¨ªguez-Rojo ; D. Deodato Lopes ; A.M.R.C. Alex ; re ; H. Pereira ; I.D. Nogueira ; C.M.M. Duarte
• 关键词：Perfluorocarbons ; Particles from Gas Saturated Solutions (PGSS) ; Gas-filled particles ; Microbubbles ; Ultrasound triggered delivery
• 刊名：The Journal of Supercritical Fluids
• 出版年：2013
• 出版时间：October, 2013
• 年：2013
• 卷：82
• 期：Complete
• 页码：206-212
• 全文大小：1623 K

文摘

For the first time, gas-filled microparticles were successfully prepared using a supercritical fluid based technology. Low molecular weight perfluorcarbon (PFC) gases, C₃F₈ or C₄F₈, have been encapsulated into Gelucire^? 50/13 (lipid-based carrier: polyethylene glycol glycerides), using PGSS^? (Particles from Gas Saturated Solution) technique. Particles were produced from the fast expansion of the melted lipid carrier saturated with a mixture of (CO₂ + PFC). The presence of the gas into the produced microparticles was verified by Nuclear Magnetic Resonance (NMR) analysis of fluorine atom. The effect of carrier to PFC mass ratio and PFC structure on the entrapment efficiency of the PFC gas into the particles was evaluated at fixed at 8.5 MPa and 353 K. These parameters were fixed in a preliminary study according to the morphology, size and flowability of the particles. The stability of encapsulated C₄F₈ in microparticles showed to be higher than C₃F₈; it was determined to be 2 h, at room conditions at the optimized carrier: PFC mass ratio of 30:1.