The effect of the plasma n-3/n-6 polyunsaturated fatty acid ratio on the dietary LDL phenotype transformation – Insights from the LIPGENE study

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• 作者：Jadwiga Hartwich ; Malgorzata Malczewska Malec ; Lukasz Partyka ; Pablo Pé ; rez-Martinez ; Carmen Marin ; Jose Ló ; pez-Mir ; a ; Audrey C. Tierney ; Jolene Mc Monagle ; Helen M. Roche ; Catherine Defoort ; Pawel Wolkow ; Aldona Dembinska-Kieć
• 关键词：n3/n6 Polyunsaturated fatty acid ratio ; LDL phenotype ; Dietary intervention
• 刊名：Clinical Nutrition
• 出版年：2009
• 出版时间：October 2009
• 年：2009
• 卷：28
• 期：5
• 页码：510-515
• 全文大小：452 K

文摘

Summary

Background & aims

LDL phenotype B is associated with obesity, insulin resistance, hypertriglyceridemia and oxidative stress. The effect of plasma n-3/n-6 PUFA ratio on LDL phenotype transformation was investigated.

Methods

Patients with metabolic syndrome (n = 99) received one of four isocaloric diets: (A) High-fat (38 % energy) SFA-rich diet (HSFA); (B) High-fat (38 % energy), MUFA-rich diet (HMUFA); (C), low-fat (LF) (28 % energy), high-complex carbohydrate diet with 1.24 g/d oleic sunflower oil (LFHCC) and (D): low-fat (28 % energy), high-complex carbohydrate diet, with 1.24 g/d LC n-3 PUFA (LFHCC n-3) for 12 weeks. Analysis of plasma lipid profile and LDL phenotype was done pre- and post-interventions.

Results

Post-dietary change of LDL density was a main effect observed in all groups. LFHCC n-3 and HFMUFA diets resulted in favorable alteration of LDL phenotype from B to A and decreased LDL density. In contrast, increased LDL density was observed in HSFA and LFHCC groups. The plasma pre-n3/n6 PUFA, Apo E change and pre-Apo CIII/CII ratios explained in 65 % the post-dietary change of LDL density in diet LFHCC n-3 consumers.

Conclusions

Study demonstrates efficacy of dietary n-3 PUFA to modify pro-atherogenic to less atherogenic LDL phenotype in patients with metabolic syndrome.

Study identifier at ClinicalTrials.gov was NCT00429195.