Sigma-1 receptor knockout mice display a depressive-like phenotype

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• 作者：Valentina Sabino ; Pietro Cottone ; Sarah L. Parylak ; Luca Steardo ; Eric P. Zorrilla
• 关键词：Antidepressant ; Neurosteroids ; Sigma-1 ; Forced swim
• 刊名：Behavioural Brain Research
• 出版年：2009
• 出版时间：17 March 2009
• 年：2009
• 卷：198
• 期：2
• 页码：472-476
• 全文大小：174 K

文摘

Activation of sigma-1 receptors (Sig-1R) reportedly has antidepressant-like action. Limited data suggest that Sig-1Rs also modulate anxiety-related behaviors. The present experiments measured depressive-like, anxiety-like and motor behavior in Sig-1R knockout mice and their wildtype littermates. Sig-1R knockout mutants showed increased immobility in the forced swimming test, a depressive-like phenotype, but normal anxiety-like behavior in the elevated plus-maze and light/dark box tests and normal locomotor activity. The results further suggest that Sig-1Rs inversely modulate depressive-like behavior.