The fucomic potential of mosquitoes: Fucosylated N-glycan epitopes and their cognate fucosyltransferases
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- 作者：Simone Kurza ; 1 ; Jonas G. Kingb ; 2 ; Rhoel R. Dinglasanb ; Katharina Paschingera ; Iain B.H. Wilsona ; iain.wilson@boku.ac.at" class="auth_mail" title="E-mail the corresponding author
- 关键词：Anopheles gambiae ; Fucosyltransferases ; Anti-HRP ; N-glycans ; Immunofluorescence ; Mass spectrometry
- 刊名：Insect Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：68
- 期：Complete
- 页码：52-63
- 全文大小：2076 K
文摘
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We revealed the neural specificity of anti-HRP in Anopheles gambiae.
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Identification of the relevant genes involved in biosynthesis of fucosylated N-glycans in the mosquito.
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Native fucosylated N-glycans of the malaria vector were characterised.
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Robust MALDI-TOF MS based assays demonstrated in vitro enzymatic activity of three fucosyltransferases.