Metabolism profiles of icariin in rats using ultra-high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry and in vitro enzymatic study
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- 作者：Tao Chenga ; b ; Tingting Shenga ; b ; Yaxiong Yia ; b ; Tong Zhanga ; b ; zhangtdmj@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Han Hana ; pashanhan@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Icariin ; Metabolite characterization ; UHPLC/QTOF-MS ; Rats ; Enzymatic study
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：1033-1034
- 期：Complete
- 页码：353-360
- 全文大小：1719 K
文摘
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UHPLC/Q-TOF-MS is used for the characterization of icariin metabolites in rats.
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Icariin mainly undergoes four metabolic pathways in vivo.
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Five metabolites are reported for the first time.
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The conjugated metabolites were further confirmed by in vitro enzymatic method.