Caulerpenyne–colchicine hybrid: Synthesis and biological evaluation
详细信息 查看全文
- 作者：Julien Bourdron ; Laurent Commeiras ; Pascale Barbier ; Vé ; ronique Bourgarel-Rey ; Eddy Pasquier ; Nicolas Vanthuyne ; Jean-Claude Hubaud ; Vincent Peyrot and Jean-Luc Parrain
- 关键词：Caulerpenyne ; Colchicine ; Biological evaluation ; Tubulin polymerization ; Cell cytotoxicity ; In vitro angiogenesis
- 刊名：Bioorganic and Medicinal Chemistry
- 出版年：2006
- 出版时间：15 August 2006
- 年：2006
- 卷：14
- 期：16
- 页码：5540-5548
- 全文大小：249 K
文摘
The synthesis of an analog of caulerpenyne having a trimethoxyaryl moiety was achieved in 11 % overall yield over 11 steps. Its biological activity has been evaluated as inhibitor of in vitro tubulin polymerization or angiogenesis.