Hematopoietic Progenitor Cell Mobilization with Ifosfamide, Carboplatin, and Etoposide Chemotherapy versus Plerixafor-Based Strategies in Patients with Hodgkin and Non-Hodgkin Lymphoma
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- 作者：Binod Dhakal1 ; Lauren Westfall Veltri2 ; Timothy S. Fenske1 ; Daniel Eastwood1 ; Michael D. Craig2 ; Aaron Cumpston2 ; Alexandra Shillingburg2 ; Jean Esselman1 ; Kathy Watkins2 ; Marcelo C. Pasquini1 ; Anita D'Souza1 ; Parameswaran Hari1 ; Abraham Sebastian Kanate2 ; Mehdi Hamadani1 ; mhamadani@mcw.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Plerixafor ; Granulocyte colony&ndash ; stimulating factor (G-CSF) ; Ifosfamide ; carboplatin ; and etoposide (ICE) ; Lymphoma ; Chemo-mobilization ; CD34
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：22
- 期：10
- 页码：1773-1780
- 全文大小：515 K
文摘
We performed a comparative analysis of safety and efficacy of chemo-mobilization versus a plerixafor-based approach in 98 lymphoma patients
Chemo-mobilization provided a significantly higher total CD34+ cell yield
No difference was seen in the number of apheresis sessions
Chemo-mobilization was associated with higher transfusion requirements (both platelet and red blood cells) and comparable other toxicities
Chemo-mobilization was associated with significantly less total mobilization cost than plerixafor-based approaches