Self-assembled monolayer of SH-DNA strand on a magnetic bar carbon paste electrode modified with Fe3O4@Ag nanoparticles for detection of breast cancer mutation
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- 作者：A. Benvidi ; abenvidi@yazd.ac.ir" class="auth_mail" title="E-mail the corresponding author ; benvidi89@gmail.com" class="auth_mail" title="E-mail the corresponding author ; S. Jahanbani
- 关键词：Fe3O4@Ag nanoparticles ; Magnetic bar carbon paste electrode (MBCPE) ; Electrochemical impedance spectroscopy (EIS) ; DNA detection
- 刊名：Journal of Electroanalytical Chemistry
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：768
- 期：Complete
- 页码：47-54
- 全文大小：1192 K
文摘
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We have designed the MBCPE/Fe3O4NPs@Ag for determination of breast cancer mutation (BRCA1).
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Use of magnetic bar for fabrication of MBCPE for completely attraction of Fe3O4@Ag on the electrode surface.
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The thiolated single stranded DNA (SH-DNA) molecules were self-assembled at the surface of MBCPE/Fe3O4@Ag.
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The proposed electrode showed a detection limit as low as 3.0 × 10-17 M for BRCA1.
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The high sensitivity, selectivity, repeatability and stability are the advantages of the proposed electrode.