Newly discovered tachykinins raise new questions about their peripheral roles and the tachykinin nomenclature

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• 作者：Patacchini ; Riccardo ; Lecci ; Alessandro ; Holzer ; Peter ; Maggi ; Carlo Alberto
• 刊名：Trends in Pharmacological Sciences
• 出版年：2004
• 出版时间：January, 2004
• 年：2004
• 卷：25
• 期：1
• 页码：1-3
• 全文大小：104 K

文摘

The tachykinin family has recently been extended by the discovery of a third tachykinin gene encoding previously unknown mammalian tachykinins (hemokinin 1, endokinin A and endokinin B) that have a widespread peripheral distribution and a tachykinin NK₁ receptor selectivity. This and the identification of other tachykinin-like peptides such as C14TKL-1 and virokinin raise many questions about the roles played by tachykinins in peripheral tissues and render terms such as ‘neurokinins’ and ‘SP receptor’ inappropriate.