Effects of capsaicin on visceral smooth muscle: a valuable tool for sensory neurotransmitter identification
详细信息 查看全文
- 作者：Barth?? ; Lorand ; Benk?? ; Rita ; Patacchini ; Riccardo ; Peth?? ; Gabor ; Holzer-Petsche ; Ulrike ; et. al.
- 关键词：Capsaicin ; Sensory neurotransmitter ; Visceral smooth muscle ; Gastrointestinal tract ; Bronchial smooth muscle ; Genitourinary tract
- 刊名：European Journal of Pharmacology
- 出版年：2004
- 出版时间：October 1, 2004
- 年：2004
- 卷：500
- 期：1-3
- 页码：143-157
- 全文大小：228 K
文摘
Studying the visceral effects of the sensory stimulant capsaicin is a useful and relatively simple tool of neurotransmitter identification and has been used for this purpose for approximately 25 years in the authors' and other laboratories. We believe that conclusions drawn from experiments on visceral preparations may have an impact on studies dealing with the central endings of primary afferent neurons, i.e. research on nociception at the spinal level. The present review concentrates on the effects of capsaicinaaathrough the transient receptor potential vanilloid receptor type 1 (TRPV1) receptoraaaon innervated gastrointestinal, respiratory and genitourinary smooth muscle preparations. Tachykinins and calcitonin gene-related peptide (CGRP) are the most widely accepted transmitters to mediate aaalocal efferentaaa effects of capsaicin-sensitive nerves in tissues taken from animals. Studies more and more frequently indicate a supra-additive interaction of various types of tachykinin receptors (tachykinin NK1, NK2, NK3 receptors) in the excitatory effects of capsaicin. There is also evidence for a mediating role of ATP, acting on P2 purinoceptors. Non-specific inhibitory actions of capsaicin-like drugs have to be taken into consideration while designing experiments with these drugs. Results obtained on human tissues may be sharply different from those of animal preparations. Capsaicin potently inhibits tone and movements of human intestinal preparations, an effect mediated by nitric oxide (NO) and/or vasoactive intestinal polypeptide.