- 作者：Tatjana Paternostro-Sluga ; M. Nuhr ; Ch. Kermer ; Th. Lang ; A. Sabbas ; V. Fialka-Moser
- 关键词：rabbit ; fibrillation potentials ; nerve lesion ; muscle denervation ; needle electromyography
- 刊名：Journal of Experimental Animal Science
- 出版年：2002
- 出版时间：August 2002
- 年：2002
- 卷：42
- 期：2
- 页码：113-121
- 全文大小：1385 K
Summary
The aim of the study was to assess the quantitative expression and amplitude of fibrillation potentials after 4 months of complete denervation in New Zealand White rabbit tibialis anterior muscles and to compare methods to quantify fibrillation potentials.Nine adult female New Zealand White rabbits with completely denervated tibialis anterior muscle due to resection of the peroneal nerve and muscle nerve muscle neurotization without reinnervation were evaluated. Axonal degeneration and muscle denervation were documented by histological examination. Needle electromyography was performed after 4 months of denervation. Quantitative expression of fibrillation potentials was assessed by recording the firing rate per second, grading according to Daube's score for the overall muscle and grading according to a modified score for each recording site. The highest amplitude of each recording site was measured peak to peak. Statistical evaluation was done descriptively and Wilxocon's signet-rank test was performed to compare firing rates between different grades.
Fifty-nine single recording sites were examined for denervated tibialis anterior muscle. The mean firing rate of FPs for all recording sites was 247.2 ± 96.7 pulses/s. Grading for the overall muscle according to Daube's score showed 3–4+ activity for all muscles. Grading for single recording sites according to the modified score showed 4+ activity in 45.8 % of recording sites, 3+ activity in 44,1 % and 2+ activity in 10.1 % .
The study provides quantitative electrophysiological data of fibrillation potentials in completely denervated rabbit tibialis anterior muscle and presents methods of quantification.