Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases

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• 作者：L Silvia Munoz-Price ; Laurent Poirel ; Robert A Bonomo ; Mitchell J Schwaber ; George L Daikos ; Martin Cormican ; Giuseppe Cornaglia ; Javier Garau ; Marek Gniadkowski ; Mary K Hayden ; Karthikeyan Kumarasamy ; David M Livermore ; Juan J Maya ; Patrice Nordmann ; Jean B Patel ; David L Paterson ; Johann Pitout ; Maria Virginia Villegas ; Hui Wang ; Neil Woodford ; et al.
• 刊名：The Lancet Infectious Diseases
• 出版年：2013
• 出版时间：September, 2013
• 年：2013
• 卷：13
• 期：9
• 页码：785-796
• 全文大小：253 K

文摘

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Summary

Klebsiella pneumoniae carbapenemases (KPCs) were originally identified in the USA in 1996. Since then, these versatile ¦Â-lactamases have spread internationally among Gram-negative bacteria, especially K pneumoniae, although their precise epidemiology is diverse across countries and regions. The mortality described among patients infected with organisms positive for KPC is high, perhaps as a result of the limited antibiotic options remaining (often colistin, tigecycline, or aminoglycosides). Triple drug combinations using colistin, tigecycline, and imipenem have recently been associated with improved survival among patients with bacteraemia. In this Review, we summarise the epidemiology of KPCs across continents, and discuss issues around detection, present antibiotic options and those in development, treatment outcome and mortality, and infection control. In view of the limitations of present treatments and the paucity of new drugs in the pipeline, infection control must be our primary defence for now.