Structure, biochemistry, and biology of PAK kinases

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• 作者：Rakesh Kumar^a ; ^b ; ^{bcmrxk@gwu.edu} ; Rahul Sanawar^b ; Xiaodong Li^c ; Feng Li^c ; ^{fli@mail.cmu.edu.cn}
• 关键词：PAK ; p21-activated kinase ; AID ; auto-inhibitory domain ; PBD ; p21-binding domain
• 刊名：Gene
• 出版年：2017
• 出版时间：20 March 2017
• 年：2017
• 卷：605
• 期：Complete
• 页码：20-31
• 全文大小：1731 K
• 卷排序：605

文摘

PAKs act as modifiers of the cell surface and intracellular signaling cascades. PAKs function both in the cytoplasm and nucleus and regulation of gene expression. Relevance of PAKs ranges from cellular homeostasis to pathobiology of human disease. PAKs are dysregulated in cancer, and neurological, cardiac and other disorders. Modifying PAK activity has emerged as a therapeutic approach for many disorders.