30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology

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• 作者：Qian Zhang¹ ; Michael J. Lenardo² ; ^{lenardo@nih.gov} ; David Baltimore³
• 关键词：genomics ; NF-κB ; I-κB ; human gene ; Rel ; immunity ; lymphocyte ; gene regulation ; transactivator ; genetic disease
• 刊名：Cell
• 出版年：2017
• 出版时间：12 January 2017
• 年：2017
• 卷：168
• 期：1-2
• 页码：37-57
• 全文大小：1314 K
• 卷排序：168

文摘

NF-κB was discovered 30 years ago as a rapidly inducible transcription factor. Since that time, it has been found to have a broad role in gene induction in diverse cellular responses, particularly throughout the immune system. Here, we summarize elaborate regulatory pathways involving this transcription factor and use recent discoveries in human genetic diseases to place specific proteins within their relevant medical and biological contexts.