Trace metal concentrations in hair and nails from Alzheimer’s disease patients: Relations with clinical severity

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• 作者：Emel Koseoglu ; MD^a ; ^{emelk@erciyes.edu.tr} (Professor) ; Rahmi Koseoglu ; PhD^b ; ^{rkoseoglu@erciyes.edu.tr} (Associate Professor) ; Murat Kendirci ; MD^c ; ^{drmuratkendirci@gmail.com} (Neurology Specialist) ; Recep Saraymen ; PhD^d ; ^{saraymen@erciyes.edu.tr} ; Burak Saraymen ; MD^e ; ^{drbur2011@hotmail.com}
• 关键词：AD ; Alzheimer disease ; NINCDS-ADRDA ; National Institutes of Neurological and Communicative Disorders and Stroke- Alzheimer Disease and Related Disorders
• 刊名：Journal of Trace Elements in Medicine and Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：39
• 期：Complete
• 页码：124-128
• 全文大小：536 K
• 卷排序：39

文摘

Metals, especially transition metals, seem to be important in the pathogenesis of Alzheimer disease. This study aims to determine the relationship of trace metal elements to the pathogenesis and/or course of Alzheimer Disease in terms of clinical severity.MethodsThe hair and nail trace metal levels of 62 Alzheimer Disease patients at different clinical stages (21 mild, 20 moderate, 21 severe) and 60 healthy control subjects were measured by using inductively coupled plasma-mass spectrometry. The statistical comparisons were performed with regards to the study groups, clinical stages, disease duration and age.ResultsThe patient and control groups were significantly different from each other in regards to Mn, Fe, Cu, Cd, Hg (p < 0.001), Zn (p < 0.01) in nail concentrations and, Na, Al, Pb, Co (p < 0.001), Fe, Mn (p = 0.001), Hg, Cu, Cd, K in hair concentrations (p < 0.01). No difference was detected in the levels of Mg and Ca. Nail Na level showed differences among different clinical stages of the disease (p < 0.01). In comparing the mild degree Alzheimer patients to the control group; significant differences were detected in nail Mn, Fe, Cu, Co (p < 0.001), Hg, Zn (p < 0.01) and, hair Pb, Al (p < 0.001), Na, K levels (p < 0.01).ConclusionsOur results have shown that transition and posttransition metals are especially important metals for the disease process. The relation of nail Na level with clinical stages of AD is an interesting new finding, making someone to think that alkali metals may be important in the progression of the disease.