Contemporary review on the pathogenesis of takotsubo syndrome: The heart shedding tears: Norepinephrine churn and foam at the cardiac sympathetic nerve terminals
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- 作者：Shams Y-Hassan ; shams.younis-hassan@karolinska.se ; Rodney De Palma
- 关键词：Takotsubo ; Cardiac sympathetic ; Myocardial stunning ; Pathogenesis ; Broken heart syndrome ; Shedding tears
- 刊名：International Journal of Cardiology
- 出版年：2017
- 出版时间：1 February 2017
- 年：2017
- 卷：228
- 期：Complete
- 页码：528-536
- 全文大小：1052 K
- 卷排序：228
文摘
Contemporary review on the pathogenesis of takotsubo syndrome (TS) is presented. Evidence supporting the involvement of sympathetic nervous system in the pathogenesis of TS is provided. Myocardial stunning in TS follows most probably the cardiac sympathetic nerve distribution. Evidence for the local cardiac sympathetic disruption and the consequences of norepinephrine spillover is presented. Research to confirm the relation of cardiac sympathetic nerves to the myocardial stunning regions in TS is warranted.