Intratumoral heterogeneity of steroidogenesis in aldosterone-producing adenoma revealed by intensive double- and triple-immunostaining for CYP11B2/B1 and CYP17
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- 作者：Yasuhiro Nakamuraa ; yasu-naka@patholo2.med.tohoku.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Masaaki Kitadab ; Fumitoshi Satohc ; d ; Takashi Maekawaa ; Ryo Morimotod ; Yuto Yamazakia ; Kazue Isea ; Celso E. Gomez-Sancheze ; f ; Sadayoshi Itoc ; Yoichi Araig ; Mari Dezawab ; Hironobu Sasanoa
- 关键词：Aldosterone-producing adenoma ; CYP11B1 ; CYP11B2 ; CYP17 ; Double-immunostaining ; Triple-immunostaining
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：422
- 期：Complete
- 页码：57-63
- 全文大小：2060 K
文摘
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Tumor cells co-expressing CYP11B1/B2 (hybrid cell type A) were identified in APA.
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Tumor cells co-expressing CYP11B2/17 (hybrid cell type B) were present in APA.
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Tumor cells co-expressing CYP11B1/17 (hybrid cell type C) were detected in APA.
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Tumor cells co-expressing CYP11B1/B2/17 (triple-positive cells) were identified in APA.