Estrogen receptor β in Merkel cell carcinoma: its possible roles in pathogenesis

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• 作者：Abdullah Azmahani ; PhD^a ; ^b ; Yasuhiro Nakamura ; MD ; PhD^a ; ^c ; ^{yasu-naka@patholo2.med.tohoku.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Hirotaka Ishida ; MD^a ; ^d ; Keely M. McNamara ; PhD^a ; Taku Fujimura ; MD ; PhD^e ; Takahiro Haga ; MD^e ; Akira Hashimoto ; MD^e ; Setsuya Aiba ; MD ; PhD^e ; Hironobu Sasano ; MD ; PhD^a
• 关键词：AR ; androgen receptor ; PRA ; progesterone receptor A ; PRB ; progesterone receptor B ; ERα ; estrogen receptor α ; ERβ ; estrogen receptor β ; MCC ; Merkel cell carcinoma ; FOXA1 ; forkhead box protein A1 ; CK20 ; cytokeratin 20 ; BCC ; basal cell carcinoma ; NET ; neuroendocrine tumor ; SOX2 ; sex determining region Y-box 2
• 刊名：Human Pathology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：56
• 期：Complete
• 页码：128-133
• 全文大小：1292 K

文摘

Sex steroids have been postulated to influence skin development and functions as well as its pathogenesis. MCC occurs in both sexes; however, the specific differences in pathogenesis among sexes have yet to be conclusively defined. The detailed status of sex steroid receptors (AR, PRA and PRB, and ERα, ERβ) are also unknown in MCC patients. We first immunolocalized sex steroid receptors and compared the results with immunolocalization of relevant transcription factors including SOX2, FOXA1, and Bcl-2 and Ki-67 in 18 cases of MCCs. AR, PRA, PRB, ERα, ERβ, Bcl-2, SOX2, and FOXA1 immunoreactivity was evaluated by using the modified H score method, and Ki-67 was quantified using labeling index. ERβ immunoreactivity was markedly present in all the cases of MCC examined, with relatively weak immunoreactivity of ERα, AR, PRA, and PRB. The status of ERβ immunoreactivity was also significantly correlated with Ki-67 labeling index and Bcl-2 score. These results demonstrated that ERβ could be associated with regulation of both cell proliferation and apoptosis in MCCs.