Estrogen-related receptor ¦Á in normal adrenal cortex and adrenocortical tumors: Involvement in development and oncogenesis

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• 作者：Saulo J.A. Felizola^a ; Yasuhiro Nakamura^a ; ^{yasu-naka@patholo2.med.tohoku.ac.jp} ; Xiao-Gang Hui^a ; Fumitoshi Satoh^b ; Ryo Morimoto^b ; Keely M.McNamara^a ; Sanae Midorikawa^c ; Shinichi Suzuki^d ; William E. Rainey^e ; Hironobu Sasano^a
• 关键词：NAC ; normal adrenal cortex ; ACT ; adrenocortical tumors ; APA ; aldosterone producing adenoma ; CPA ; cortisol producing adenoma ; ACC ; adrenocortical carcinoma ; NC ; neocortex ; FZ ; fetal zone ; ZG ; zona glomerulosa ; ZF ; zona fasciculate ; ZR ; zona reticularis ; LI
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2013
• 出版时间：30 January, 2013
• 年：2013
• 卷：365
• 期：2
• 页码：207-211
• 全文大小：844 K

文摘

class=""h4"">Aims

The nuclear hormone receptor estrogen-related receptor ¦Á (ERR¦Á) regulates the activation of mitochondrial genes in various human tissues, but its role in the adrenal gland and its disorders has not been defined. Therefore, we examined ERR¦Á expression in both normal adrenal cortex (NAC) and adrenocortical tumor (ACT) in order to study the possible correlation of ERR¦Á with adrenal development and tumor development.

class=""h4"">Methods

Human adrenal specimens (non-pathological fetal n = 7; non-pathological post-birth n = 40; aldosterone producing adenoma (APA) n = 11; cortisol producing adenoma (CPA) n = 11; adrenocortical carcinoma (ACC) n = 8) were immunohistochemically examined in this study. NAC (n = 13) and ACT (n = 28) frozen tissue specimens were also available for studying ERR¦Á mRNA levels.

class=""h4"">Key findings

In fetal NAC tissues, ERR¦Á labeling index (LI) in fetal zone (FZ) was significantly higher that that in neocortex (NC), and the differences among age groups for overall mean LI was statistically significant when analyzed according to individual cortical layers. ERR¦Á LI was also significantly higher in ACC than in other types of ACT. ERR¦Á mRNA was detected in NAC and all types of ACT.

class=""h4"">Significance

Results of our present study suggest a possible role of ERR¦Á in adrenal development and ACC.