Skeletal muscle-specific overexpression of IGFBP-2 promotes a slower muscle phenotype in healthy but not dystrophic mdx mice and does not affect the dystrophic pathology

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• 作者：Kristy Swiderski^a ; Karen Janet Bernice Martins^a ; ¹ ; Annabel Chee^a ; Jennifer Trieu^a ; Timur Naim^a ; Stefan Martin Gehrig^a ; Dale Michael Baum^a ; Julia Brenmoehl^b ; Luong Chau^b ; René ; Koopman^a ; Paul Gregorevic^c ; Friedrich Metzger^d ; Andreas Hoeflich^b ; Gordon Stuart Lynch^a ; ^{gsl@unimelb.edu.au}
• 关键词：IGFBP-2 ; Dystrophy ; Muscle ; Fiber type ; Muscle function
• 刊名：Growth Hormone & IGF Research
• 出版年：2016
• 出版时间：October-December 2016
• 年：2016
• 卷：30-31
• 期：Complete
• 页码：1-10
• 全文大小：1603 K
• 卷排序：30

文摘

Comparative analysis of the IGFBPs in control and dystrophic mouse muscle Increased IGFBP-2 promotes a slower muscle program in control but not mdx mice. Highlights possible role of dystrophin-glycoprotein complex in signaling required for this adaptation