Xanthohumol enhanced 28 microRNA expressions and downregulated 3 microRNA levels in inducing glioblastoma apoptotic death.
The miR-204-3p levels is the most significantly upregulated microRNA in xanthohumol-treated glioma cells.
Xanthohumol upregulated miR-204-3p levels via ERK/c-Fos pathway.
IGFBP2 was validated as a direct target gene of miR-204-3p.
The miR-204-3p-targeted IGFBP2/AKT/Bcl2 pathway is involved in xanthohumol cytotoxicity.