The protective effects of paeonol against epirubicin-induced hepatotoxicity in 4T1-tumor bearing mice via inhibition of the PI3K/Akt/NF-kB pathway
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- 作者：Jing Wua ; b ; Xia Xuea ; Bin Zhanga ; Wen Jiangc ; Hongmei Caod ; Rongmei Wanga ; Deqing Suna ; sundq0405@126.com" class="auth_mail" title="E-mail the corresponding author ; Ruichen Guoe ; grc7636@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Epirubicin ; Breast cancer ; Paeonol ; Hepatotoxicity ; PI3K/Akt/NF-kB
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：25 January 2016
- 年：2016
- 卷：244
- 期：Complete
- 页码：1-8
- 全文大小：3157 K
文摘
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Epirubicin is widely used to treat breast cancer, but limited for its hepatotoxicity.
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Paeonol could alleviate epirubicin-induced hepatotoxicity in 4T1-tumor bearing mice.
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The mechanism relies on inhibiting the PI3K/Akt/NF-kB pathway.