Single-center retrospective study evaluating patients who had a diagnosis of LC during a 10-year period. Diagnosis was made by malignant cytology or imaging; suspicious cases treated as LC were also included.<h4 class=""h4"">Resultsh4>
Fifty patients with LC were analyzed (58 % women). Median age was 54.4 years, and KPS was 60 % . The most common types of tumor were breast (35 % ), lung (24 % ), and hematologic malignancies (16 % ). Thirty-two percent of patients were diagnosed by imaging, 22 % by cytology, and 40 % by both. Median overall survival (OS) was 10 weeks (95 % confidence interval 5.1-14.9). Median OS for patients who received specific treatment was 21.2 weeks vs. 6.38 weeks for patients receiving supportive care only (p < 0.001). In multivariate analysis, initial KPS, initial CSF protein level (<112 mg/dL) and time from diagnosis of primary tumor to diagnosis of LC (>67 weeks) were significant and independent predictors of increased survival.<h4 class=""h4"">Conclusionsh4>
Prognosis remains poor in LC. The predictive factors for patients with LC here identified could help to improve the selection of patients who are more likely to benefit from receiving treatment.