Polymorphism of dopamine D2 receptor (TaqIA, TaqIB, and-141C Ins/Del) and dopamine degradation enzyme (COMT G158A, A-278G) genes and extrapyramidal symptoms in patients with schizophrenia and bipolar

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• 作者：Amalia Lafuente ; Miquel Bernardo ; Sergi Mas ; Anna Crescenti ; Monica Aparici ; Patricia Gasso ; Ramon Deulofeu ; Anna Mane ; Rosa Catalan ; Xavier Carne
• 关键词：Catechol-O-methyltransferase ; D2 receptor gene ; Schizophrenia ; Bipolar disorders ; Extrapyramidal symptoms ; Pharmacogenetics
• 刊名：Psychiatry Research
• 出版年：2008
• 出版时间：30 November 2008
• 年：2008
• 卷：161
• 期：2
• 页码：131-141
• 全文大小：236 K

文摘

Objective

The relationship is examined of the dopamine D2 receptor (DRD2) polymorphism (TaqIA, TaqIB, − 141 C Ins/Del) and the catechol-O-methyltransferase (COMT) polymorphism (A-278G, G158A) to the risk of antipsychotic-induced extrapyramidal symptoms (EPS) in schizophrenia and bipolar disorders. Participants comprised 80 cases presenting with EPS (Simpson-Angus Scale score > 3) and 188 controls presenting without EPS (Simpson-Angus Scale score ≤ 3) participated in this study. The COMT^L allele conferred a reduction of EPS risk of 60 % to heterozygotes, but the finding did not survive correction for multiple comparisons. In the bipolar subgroup, with a COMT^L allele protection of 70 % , the reduction remained significant after Bonferroni correction. The analysis of the COMT haplotypes revealed an association of the A–G haplotype with EPS risk in the overall group and the bipolar disorder subgroup, and an association of the A–A haplotype with EPS protection in the bipolar subgroup. No significant associations were found for DRD2 or COMT A-278G polymorphisms. This is the first report of an association between the COMT polymorphism and EPS susceptibility. These results are of interest in view of the increased use of antipsychotic drugs in bipolar patients in both the acute manic and the depressive phase.