Inhibition of cocaine self-administration by fluoxetine or d-fenfluramine combined with phentermine

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• 作者：Glatz ; Andrew C. ; Ehrlich ; Michelle ; Bae ; Richard S. ; Clarke ; Michelle J. ; Quinlan ; Patricia A. ; et. al.
• 关键词：Cocaine ; Self-administration ; d-Fenfluramine ; Fenfluramine ; Phentermine ; Fluoxetine ; Speedball ; Heroin ; Rat
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：2002
• 出版时间：January - February, 2002
• 年：2002
• 卷：71
• 期：1-2
• 页码：197-204
• 全文大小：124 K

文摘

Instrumental responding for intravenous cocaine in rats at 85 % of free-feeding weight was significantly decreased 50 % by d-fenfluramine plus phentermine (d-Fen/Phen, 5 mg/kg of each for 1 day). A similar effect was obtained in normal-weight rats self-administering a cocaine–heroin mixture. Treating normal-weight animals with fluoxetine (5 mg/kg) for 4 days also significantly decreased cocaine self-administration by half, and then adding phentermine caused an additional decrease in cocaine intake. Animals that were well trained to self-administer drug did not self-administer intravenous d-Fen/Phen or Flu/Phen. The present results confirm that serotonergic drugs can decrease cocaine, or cocaine/heroin, self-administration in rats, and that phentermine adds to the effect. Based on related research with the same dose of d-Fen/Phen, it is suggested that effectiveness in reducing cocaine reinforcement is due in part to a satiating effect in which dopamine and acetylcholine are released in the nucleus accumbens.