Neurotransmitter receptor and regulatory gene expression in peripheral blood of Brazilian drug-na茂ve first-episode psychosis patients before and after antipsychotic treatment
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- 作者：Vanessa Kiyomi Ota ; Cristiano Noto ; Ary Gadelha ; Marcos Leite Santoro ; Patricia Natalia Silva ; Maria Isabel Melaragno ; Mar铆lia de Arruda Cardoso Smith ; Quirino Cordeiro ; Rodrigo Affonseca Bressan ; Sintia Iole Belangero
- 关键词：Schizophrenia ; GABRR2 ; CHRNA3
- 刊名：Psychiatry Research
- 出版年：30 December, 2013
- 年：2013
- 卷：210
- 期：3
- 页码：1290-1292
- 全文大小：203 K
文摘
Little is known about how genes expressed in blood relate to schizophrenia or antipsychotic use. We analyzed gene expression in 10 first-episode psychosis patients and nine controls using PCR Arrays. GABRR2 and CHRNA3 were found to be differentially expressed after risperidone treatment. These genes may be regulated by antipsychotic use.