G-protein coupled receptor 6 deficiency alters striatal dopamine and cAMP concentrations and reduces dyskinesia in a mouse model of Parkinson's disease
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- 作者：Patrick Oeckl1 ; Bastian Hengerer ; Boris Ferger ; boris.ferger@boehringer-ingelheim.com" class="auth_mail
- 关键词：GPR6 ; cAMP ; Dopamine ; Parkinson's disease ; Dyskinesia ; 6-Hydroxydopamine ; In vivo microdialysis ; Apomorphine
- 刊名：Experimental Neurology
- 出版年：July 2014
- 年：2014
- 卷：257
- 期：Complete
- 页码：1-9
- 全文大小：1071 K
文摘
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Gpr6 deficiency leads to a reduction of striatal cAMP and an increase of dopamine.
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P-DARPP-32 concentrations are increased in the striatum of Gpr6 deficient mice.
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Gpr6 deficient mice show higher basal locomotor activity.
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Higher basal locomotor activity persists after haloperidol treatment.
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Gpr6 deficiency reduces dyskinesia in a mouse model of Parkinson's disease.