Transitions for Regulating Early Transcription

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• 作者：Margaux Michel¹ ; Patrick Cramer¹ ; ^{cramer@LMB.uni-muenchen.de}
• 刊名：Cell
• 出版年：2013
• 出版时间：23 May, 2013
• 年：2013
• 卷：153
• 期：5
• 页码：943-944
• 全文大小：229 K

文摘

Gene expression is largely regulated during the initiation of RNA polymerase II (PolII) transcription. In this issue, Kouzine et?al. show that control of DNA melting is one of the critical rate-limiting steps for productive mRNA elongation. We discuss these findings in the context of other key energetic transitions.