Increased neonatal fat mass, not lean body mass, is associated with maternal obesity

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• 作者：Mark F. Sewell ; Larraine Huston-Presley ; Dennis M. Super ; Patrick Catalano
• 关键词：Pregnancy ; Obesity ; Body mass index ; Body fat
• 刊名：American Journal of Obstetrics and Gynecology
• 出版年：2006
• 出版时间：October 2006
• 年：2006
• 卷：195
• 期：4
• 页码：1100-1103
• 全文大小：140 K

文摘

Objective

The purpose of this study was to compare body composition measures in neonates of women who were overweight/obese (body mass index, ≥25 kg/m²) versus women who were lean/average (body mass index, <25 kg/m²), all of whom had normal glucose tolerance levels.

Study design

Seventy-six neonates (34 female and 42 male) of singleton pregnancies of pregravid overweight/obese women and 144 neonates (67 female and 77 male) of lean/average women were assessed with anthropometric measures and total body electrical conductivity evaluation of body composition at birth.

Results

There was a borderline increase in birthweight (3436 ± 567 g vs 3284 ± 534 g; P = .051) but not lean body mass (3020 ± 410 g vs 2950 ± 400 g; P = .23) in the overweight/obese versus lean/average weight groups. However, there were significant increases in percent body fat (11.6 % ± 4.7 % vs 9.7 ± 4.3 % ; P = .003) and fat mass (420 ± 220 g vs 380 ± 170 g; P = .01) in neonates of overweight/obese women versus lean/average weight women.

Conclusion

Overweight/obese women with normal glucose tolerance levels have neonates who are heavier than lean/average weight women because of increased adiposity. We speculate that this increased obesity in offspring of obese women with normal glucose tolerance levels is a significant risk for adolescent obesity and components of the metabolic syndrome.